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Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer.

Cancer research - 15 Oct 2008

Chiang Shang-Lun, Chen Ping-Ho, Lee Chien-Hung, Ko Albert Min-Shan, Lee Ka-Wo, Lin Ying-Chu, Ho Pei-Shan, Tu Hung-Pin, Wu Deng-Chyang, Shieh Tien-Yu, Ko Ying-Chin

Abstract excerpt

Because the mRNA expression of cyclooxygenase-2 (COX-2) is up-regulated by arecoline in human gingival fibroblasts, as shown in our previous study, we further investigated the mRNA expression level of COX-2 and its upstream effectors in three oral epithelial carcinoma cell lines (KB, SAS, and Ca9-22) by using areca nut extract (ANE) and saliva-reacted ANE (sANE). A case-control study of 377 oral squamous cell...

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PMID: 18922923
DOI: 10.1158/0008-5472.CAN-08-0823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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