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Article

Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis.

International journal of molecular sciences - 30 Oct 2020

Cheng Ru-Hsiu, Wang Yi-Ping, Chang Julia Yu-Fong, Pan Yu-Hwa, Chang Mei-Chi, Jeng Jiiang-Huei

Abstract excerpt

Betel quid (BQ) chewing increased the risk of oral cancer and oral submucous fibrosis (OSMF), an oral premalignant disorder (OPMD) with malignant transformation potential. BQ components such as areca nut (AN), trauma by coarse AN fiber, catechin, copper, alkaloids, stimulated reactive oxygen species (ROS), inflammation and cytotoxicity are suggested to be the contributing factors. They may induce tissue...

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Identifiers

PMID: 33143101
DOI: 10.3390/ijms21218104
PMCID: PMC7663238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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