Article
The influence of monoamine oxidase variants on the risk of betel quid-associated oral and pharyngeal cancer.
TheScientificWorldJournal - 1 Jan 2014
Chen Ping-Ho, Huang Bin, Shieh Tien-Yu, Wang Yan-Hsiung, Chen Yuk-Kwan, Wu Ju-Hui, Huang Jhen-Hao, Chen Chun-Chia, Lee Ka-Wo
Abstract excerpt
Betel quid (BQ) and areca nut (AN) (major BQ ingredient) are group I human carcinogens illustrated by International Agency for Research on Cancer and are closely associated with an elevated risk of oral potentially malignant disorders (OPMDs) and cancers of the oral cavity and pharynx. The primary alkaloid of AN, arecoline, can be metabolized via the monoamine oxidase (MAO) gene by inducing reactive oxygen...
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