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Rational Modifications of HIV-1 Envelope Glycoproteins for Immunogen Design

31 Dec 2006

Abstract excerpt

An effective vaccine against the human immunodeficiency virus type 1 (HIV-1) will likely require the elicitation of broadly neutralizing antibodies as well as cellular responses. The HIV exterior envelope glycoprotein trimers, gp120, and the transmembrane glycoprotein, gp41, mediate entry and are the sole viral targets for neutralizing antibodies. However, as subunit immunogens the envelope glycoproteins do not...

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PMID: 17269929
DOI: 10.2174/138161207779313632

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