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Article

Distinct p53 genomic binding patterns in normal and cancer-derived human cells

15 Dec 2011

Abstract excerpt

We report here genome-wide analysis of the tumor suppressor p53 binding sites in normal human cells. 743 high-confidence ChIP-seq peaks representing putative genomic binding sites were identified in normal IMR90 fibroblasts using a reference chromatin sample. More than 40% were located within 2 kb of a transcription start site (TSS), a distribution similar to that documented for individually studied, functional...

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PMID: 22127205
DOI: 10.4161/cc.10.24.18383

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