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Article

Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity.

Cell cycle (Georgetown, Tex.) - 1 Sept 2012

Quante Timo, Otto Benjamin, Brázdová Marie, Kejnovská Iva, Deppert Wolfgang, Tolstonog Genrich V

Abstract excerpt

The molecular mechanisms underlying mutant p53 (mutp53) "gain-of-function" (GOF) are still insufficiently understood, but there is evidence that mutp53 is a transcriptional regulator that is recruited by specialized transcription factors. Here we analyzed the binding sites of mutp53 and the epigenetic status of mutp53-regulated genes that had been identified by global expression profiling upon depletion of...

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Identifiers

PMID: 22894900
DOI: 10.4161/cc.21646
PMCID: PMC3466528

Genes

GAS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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