Article
C4A deficiency and poor prognosis in patients with IgA nephropathy.
Clinical nephrology - 1 Jul 1991
Wyatt R J, Julian B A, Woodford S Y, Wang C, Roberts J, Thompson J S, Christenson M J, McLean R H
Abstract excerpt
IgA nephropathy (Berger's disease) is an important cause of end-stage renal failure in persons of Asian and European descent. We performed C4 phenotyping on plasma from 123 patients with IgA nephropathy who resided in several different parts of the United States. All of these patients underwent diagnostic renal biopsy in adulthood. Six patients had a total deficiency for the C4A protein and all six had chronic...
Topics
- Chromosome Deletion
- Complement C4a
- Female
- Genetic Predisposition to Disease
- Glomerulonephritis, IGA
- Histocompatibility Testing
- Humans
- Immunophenotyping
- Kidney Failure, Chronic
- Male
- Prognosis