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Article

Repression of the murine interferon alpha 11 gene: identification of negatively acting sequences.

Nucleic acids research - 25 Aug 1991

Civas A, Dion M, Vodjdani G, Doly J

Abstract excerpt

The uninducible murine interferon alpha 11 gene (Mu IFN-alpha 11) shows strong homology with the highly inducible Mu IFN-alpha 4 gene in the promoter region. Negative regulatory sequences located between positions -470 and -145 were characterized in the Mu IFN-alpha 11 promoter. The removal of these sequences leads to virus-inducibility of Mu IFN-alpha 11 while their insertion in Mu IFN-alpha 4 corresponding...

Topics

Animals
Base Sequence
Cell Line
Gene Expression Regulation
Humans
Interferon Type I
Mice
Molecular Sequence Data
Mutation
Newcastle disease virus
Plasmids
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Regulatory Sequences, Nucleic Acid

Sequence Homology, Nucleic Acid

Thymidine Kinase

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1886773
DOI: 10.1093/nar/19.16.4497
PMCID: PMC328640

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1886773-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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