Activation of IFN-<i>β</i>element by IRF-1 requires a post-translational event in addition to IRF-1 synthesis

doi:10.1093/nar/19.16.4421

Article

Activation of IFN-<i>β</i>element by IRF-1 requires a post-translational event in addition to IRF-1 synthesis

1 Jan 1991

Abstract excerpt

Expression of the Type I IFN (i.e., IFN-alpha s and IFN-beta) genes is efficiently induced by viruses at the transcriptional level. This induction is mediated by at least two types of positive regulatory elements located in the human IFN-beta gene promoter: (1) the repeated elements which bind both the transcriptional activator IRF-1 and the repressor IRF-2 (IRF-elements; IRF-Es), and (2) the kappa B element...

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.