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Article

Characterization of Specific DNA-binding Factors Activated by Double-stranded RNA as Positive Regulators of Interferon α/β-stimulated Genes

1 Oct 1995

Abstract excerpt

Viral infection results in transcriptional activation of the cellular interferon alpha/beta-stimulated genes (ISGs) independent of the autocrine action of interferon alpha/beta (IFN-alpha/beta). Induction of ISG expression by virus appears to be mediated through production of viral double-stranded RNA (dsRNA). Previously, we identified two novel dsRNA-activated factors (DRAFs) that bind to the...

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PMID: 7559546
DOI: 10.1074/jbc.270.40.23739

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