Article
Analysis of the role of E2A-encoded proteins in insulin gene transcription.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 1997
Sharma A, Henderson E, Gamer L, Zhuang Y, Stein R
Abstract excerpt
Pancreatic beta-cell type-specific transcription of the insulin gene is mediated, in part, by factors in the basic helix-loop-helix (bHLH) family that act on a site within the insulin enhancer, termed the E1-box. Expression from this element is regulated by a heteromeric protein complex containin...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Cell Line
- DNA-Binding Proteins
- Dimerization
- Enhancer Elements, Genetic
- Genotype
- Glucagon
- Helix-Loop-Helix Motifs
- Humans
- Insulin
- Islets of Langerhans
- Macromolecular Substances
- Mice
- Mice, Knockout
- Somatostatin
- TCF Transcription Factors
- Trans-Activators