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Article

The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking.

Journal of lipid research - 1 Feb 2004

Zhang Jessie, Dudley-Rucker Nicole, Crowley Jan R, Lopez-Perez Elvira, Issandou Marc, Schaffer Jean E, Ory Daniel S

Abstract excerpt

Recently, a new class of lipid-lowering agents has been described that upregulate LDL receptor (LDLr) activity. These agents are proposed to activate sterol-regulated gene expression through binding to the sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP). Here, we show that the steroidal LDLr upregulator, GW707, induces accumulation of lysosomal free cholesterol and inhibits...

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Source

Identifiers

PMID: 14617742
DOI: 10.1194/jlr.M300409-JLR200

Genes

SCAP
NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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