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Article

Binding protein-independent histidine permease mutants. Uncoupling of ATP hydrolysis from transmembrane signaling.

The Journal of biological chemistry - 5 Sept 1991

Petronilli V, Ames G F

Abstract excerpt

Periplasmic permeases consist of a substrate-binding receptor, located in the periplasm, and a membrane-bound complex composed of two integral membrane proteins and two nucleotide-binding proteins. The receptor interacts with the membrane-bound complex, which, upon receiving this signal, is postulated to hydrolyze ATP and translocate the substrate. We show that a class of mutations in the membrane-bound complex...

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PMID: 1885562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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