Article
Binding protein-independent histidine permease mutants. Uncoupling of ATP hydrolysis from transmembrane signaling.
The Journal of biological chemistry - 5 Sept 1991
Petronilli V, Ames G F
Abstract excerpt
Periplasmic permeases consist of a substrate-binding receptor, located in the periplasm, and a membrane-bound complex composed of two integral membrane proteins and two nucleotide-binding proteins. The receptor interacts with the membrane-bound complex, which, upon receiving this signal, is postulated to hydrolyze ATP and translocate the substrate. We show that a class of mutations in the membrane-bound complex...
Topics
- ATP-Binding Cassette Transporters
- Adenosine Diphosphate
- Adenosine Triphosphate
- Amino Acid Transport Systems, Basic
- Arginine
- Bacterial Proteins
- Biological Transport, Active
- Cell Membrane
- Hydrolysis
- Kinetics