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How integration of positive and negative regulatory signals by a STAND signaling protein depends on ATP hydrolysis.

Molecular cell - 26 Oct 2007

Marquenet Emélie, Richet Evelyne

Abstract excerpt

The role of nucleotide hydrolysis in signaling by signal transduction ATPases with numerous domains (STAND) is poorly understood. Here we use MalT, the transcription activator of the Escherichia coli maltose regulon, as a model system to address this question. We have constructed the MalT-D129A variant that binds ATP but does not hydrolyze it and have characterized it in vivo and in vitro. ATP hydrolysis is not...

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PMID: 17964259
DOI: 10.1016/j.molcel.2007.08.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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