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Article

G-protein gene 825C>T polymorphism is associated with response to clozapine in Brazilian schizophrenics.

Pharmacogenomics - 1 Oct 2008

Kohlrausch Fabiana B, Salatino-Oliveira Angélica, Gama Clarissa S, Lobato Maria Inês, Belmonte-de-Abreu Paulo, Hutz Mara H

Abstract excerpt

AIMS: Clozapine treatment of schizophrenia is effective only in 30-60% of individuals. Since genetic factors are believed to play a significant role in the variation of response to antipsychotics, the aim of the present study was to verify the effect of a G-protein gene polymorphism on clozapine response and clozapine-induced generalized seizures in Brazilian patients with schizophrenia. PATIENTS & METHODS: In...

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Source

Identifiers

PMID: 18855531
DOI: 10.2217/14622416.9.10.1429

Genes

GNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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