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Article

The CYP1A2 -163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian schizophrenia patients.

Psychiatry research - 30 Sept 2013

Kohlrausch Fabiana Barzotti, Severino-Gama Clarissa, Lobato Maria Inês, Belmonte-de-Abreu Paulo, Carracedo Angel, Hutz Mara Helena

Abstract excerpt

We evaluated two polymorphisms at CYP1A2 (*1C and *1F) in a sample of 108 European-derived patients with schizophrenia and their influence on the pro-convulsive effect of clozapine. We found the *1F/*1F genotype to be significantly associated with seizures, and no relationship was observed with c...

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Identifiers

PMID: 23601795
DOI: 10.1016/j.psychres.2013.02.030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23601795-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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