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Article

Is PTEN loss associated with clinical outcome measures in human prostate cancer?

1 Oct 2008

Abstract excerpt

Inactivating PTEN mutations are commonly found in prostate cancer, resulting in an increased activation of Akt. In this study, we investigate the role of PTEN deletion and protein expression in the development of hormone-refractory prostate cancer using matched hormone-sensitive and hormone-refractory tumours. Fluorescent in situ hybridisation and immunohistochemistry was carried out to investigate PTEN gene...

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Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
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PMID: 18854827
DOI: 10.1038/sj.bjc.6604680

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