Article
Beyond Parkinson disease: amyotrophic lateral sclerosis and the axon guidance pathway.
PloS one - 16 Jan 2008
Lesnick Timothy G, Sorenson Eric J, Ahlskog J Eric, Henley John R, Shehadeh Lina, Papapetropoulos Spiridon, Maraganore Demetrius M
Abstract excerpt
BACKGROUND: We recently described a genomic pathway approach to study complex diseases. We demonstrated that models constructed using single nucleotide polymorphisms (SNPs) within axon guidance pathway genes were highly predictive of Parkinson disease (PD) susceptibility, survival free of PD, and age at onset of PD within two independent whole-genome association datasets. We also demonstrated that several axon...
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