Susceptibility variants for male-pattern baldness on chromosome 20p11.

doi:10.1038/ng.228

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Article

Susceptibility variants for male-pattern baldness on chromosome 20p11.

Nature genetics - 1 Nov 2008

Hillmer Axel M, Brockschmidt Felix F, Hanneken Sandra, Eigelshoven Sibylle, Steffens Michael, Flaquer Antonia, Herms Stefan, Becker Tim, Kortüm Anne-Katrin, Nyholt Dale R, Zhao Zhen Zhen, Montgomery Grant W, Martin Nicholas G, Mühleisen Thomas W, Alblas Margrieta A, Moebus Susanne, Jöckel Karl-Heinz, Bröcker-Preuss Martina, Erbel Raimund, Reinartz Roman, Betz Regina C, Cichon Sven, Propping Peter, Baur Max P, Wienker Thomas F, Kruse Roland, Nöthen Markus M

Abstract excerpt

We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that...

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PMID: 18849994
DOI: 10.1038/ng.228

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