Male-pattern baldness susceptibility locus at 20p11.

doi:10.1038/ng.255

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Article

Male-pattern baldness susceptibility locus at 20p11.

Nature genetics - 1 Nov 2008

Richards J Brent, Yuan Xin, Geller Frank, Waterworth Dawn, Bataille Veronique, Glass Daniel, Song Kijoung, Waeber Gerard, Vollenweider Peter, Aben Katja K H, Kiemeney Lambertus A, Walters Bragi, Soranzo Nicole, Thorsteinsdottir Unnur, Kong Augustine, Rafnar Thorunn, Deloukas Panos, Sulem Patrick, Stefansson Hreinn, Stefansson Kari, Spector Tim D, Mooser Vincent

Abstract excerpt

We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P =...

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PMID: 18849991
DOI: 10.1038/ng.255
PMCID: PMC2672151

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