Article
Three-dimensional growth as multicellular spheroid activates the proangiogenic phenotype of colorectal carcinoma cells via LFA-1-dependent VEGF: implications on hepatic micrometastasis.
Journal of translational medicine - 9 Oct 2008
Valcárcel María, Arteta Beatriz, Jaureguibeitia Arrate, Lopategi Aritz, Martínez Iñigo, Mendoza Lorea, Muruzabal Francisco J, Salado Clarisa, Vidal-Vanaclocha Fernando
Abstract excerpt
BACKGROUND: The recruitment of vascular stromal and endothelial cells is an early event occurring during cancer cell growth at premetastatic niches, but how the microenvironment created by the initial three-dimensional (3D) growth of cancer cells affects their angiogenesis-stimulating potential i...
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