Article
Colon carcinoma cells induce CXCL11-dependent migration of CXCR3-expressing cytotoxic T lymphocytes in organotypic culture.
Cancer immunology, immunotherapy : CII - 1 Mar 2007
Berencsi Klara, Meropol Neal J, Hoffman John P, Sigurdson Elin, Giles Lydia, Rani Pyapalli, Somasundaram Rajasekharan, Zhang Tianqian, Kalabis Jiri, Caputo Laura, Furth Emma, Swoboda Rolf, Marincola Francesco, Herlyn Dorothee
Abstract excerpt
Adoptive immunotherapy of cancer patients with cytolytic T lymphocytes (CTL) has been hampered by the inability of the CTL to home into tumors in vivo. Chemokines can attract T lymphocytes to the tumor site, as demonstrated in animal models, but the role of chemokines in T-lymphocyte trafficking toward human tumor cells is relatively unexplored. In the present study, the role of chemokines and their receptors in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.