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Article

Three-dimensional cell cultures: from molecular mechanisms to clinical applications

1 Oct 1997

Abstract excerpt

This article reviews actual advances in the development and application of three-dimensional (3-D) cell culture systems. Recent therapeutically oriented studies include characterization of multicellular-mediated drug resistance, novel ways of quantifying hypoxia, and new approaches to more efficient immunotherapy. Recent progress toward understanding the development of necrosis in tumor spheroids has been made...

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Identifiers

PMID: 9357753
DOI: 10.1152/ajpcell.1997.273.4.c1109

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