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Article

Hypoxia after liver surgery imposes an aggressive cancer stem cell phenotype on residual tumor cells.

Annals of surgery - 1 Apr 2014

Govaert Klaas M, Emmink Benjamin L, Nijkamp Maarten W, Cheung Zing J, Steller Ernst J A, Fatrai Szabolcs, de Bruijn Menno T, Kranenburg Onno, Borel Rinkes Inne H M

Abstract excerpt

OBJECTIVE: To assess the contribution of hypoxia and bone marrow-derived cells to aggressive outgrowth of micrometastases after liver surgery. BACKGROUND: Liver surgery generates a microenvironment that fosters aggressive tumor recurrence. These areas are characterized by chronic hypoxia and influx of bone marrow-derived cells. METHODS: The contribution of hematopoietic cell types was studied in mice lacking...

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PMID: 24253142
DOI: 10.1097/SLA.0b013e318295c160

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