Article
Discovery and expansion of gene modules by seeking isolated groups in a random graph process.
PloS one - 1 Jan 2008
Brumm Jochen, Conibear Elizabeth, Wasserman Wyeth W, Bryan Jennifer
Abstract excerpt
BACKGROUND: A central problem in systems biology research is the identification and extension of biological modules-groups of genes or proteins participating in a common cellular process or physical complex. As a result, there is a persistent need for practical, principled methods to infer the modular organization of genes from genome-scale data. RESULTS: We introduce a novel approach for the identification of...
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