Article

Degree-ranked gene lists omit the cross-module connectors, and a partition-free centrality recovers them

2026-08-17

Abstract excerpt

Network centrality is the workhorse of gene prioritisation, yet what a ranking omits is rarely audited. Scoring each selection against an annotation-count-matched maximum-entropy reference—asking whether a selected gene set covers the genome’s functional space or collapses it-reveals that the criterion in standard use has a measurable blind spot in exactly the class it is meant to surface. Degree, the most widely...

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Literature Corpus work: d158101f-4b10-5bb7-a9cf-08a697094f66
DOI: 10.64898/2026.08.10.743862

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