Article
ModuleDiscoverer: Identification of regulatory modules in protein-protein interaction networks.
Scientific reports - 11 Jan 2018
Vlaic Sebastian, Conrad Theresia, Tokarski-Schnelle Christian, Gustafsson Mika, Dahmen Uta, Guthke Reinhard, Schuster Stefan
Abstract excerpt
The identification of disease-associated modules based on protein-protein interaction networks (PPINs) and gene expression data has provided new insights into the mechanistic nature of diverse diseases. However, their identification is hampered by the detection of protein communities within large-scale, whole-genome PPINs. A presented successful strategy detects a PPIN's community structure based on the maximal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.