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Article

Aberrant methylation of the Adenomatous Polyposis Coli (APC) gene promoter is associated with the inflammatory breast cancer phenotype.

British journal of cancer - 18 Nov 2008

Van der Auwera I, Van Laere S J, Van den Bosch S M, Van den Eynden G G, Trinh B X, van Dam P A, Colpaert C G, van Engeland M, Van Marck E A, Vermeulen P B, Dirix L Y

Abstract excerpt

Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter occurs in about 40% of breast tumours and has been correlated with reduced APC protein levels. To what extent epigenetic alterations of the APC gene may differ according to specific breast cancer phenotypes, remains to be elucidated. Our aim was to explore the role of APC methylation in the inflammatory breast cancer (IBC) phenotype. The...

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Source

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Identifiers

PMID: 18841156
DOI: 10.1038/sj.bjc.6604705
PMCID: PMC2584952

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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