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Article

Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2010

Kauwe J S K, Bertelsen S, Mayo K, Cruchaga C, Abraham R, Hollingworth P, Harold D, Owen M J, Williams J, Lovestone S, Morris J C, Goate A M

Abstract excerpt

Alzheimer's disease (AD) is a complex disease that is likely influenced by many genetic and environmental factors. Citing evidence that iron may play a role in AD pathology, Robson et al. [Robson et al. (2004); J Med Genet 41:261-265] reported that epistatic interaction between rs1049296 (P589S) in the transferrin gene (TF) and rs1800562 (C282Y) in the hemochromatosis gene (HFE) results in significant association...

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Identifiers

PMID: 20029940
DOI: 10.1002/ajmg.b.31053
PMCID: PMC2877151

Genes

HFE
APOE

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