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Article

Alteration of ROS homeostasis and decreased lifespan in S. cerevisiae elicited by deletion of the mitochondrial translocator FLX1.

BioMed research international - 1 Jan 2014

Giancaspero Teresa Anna, Dipalo Emilia, Miccolis Angelica, Boles Eckhard, Caselle Michele, Barile Maria

Abstract excerpt

This paper deals with the control exerted by the mitochondrial translocator FLX1, which catalyzes the movement of the redox cofactor FAD across the mitochondrial membrane, on the efficiency of ATP production, ROS homeostasis, and lifespan of S. cerevisiae. The deletion of the FLX1 gene resulted in respiration-deficient and small-colony phenotype accompanied by a significant ATP shortage and ROS unbalance in...

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Identifiers

PMID: 24895546
DOI: 10.1155/2014/101286
PMCID: PMC4033422

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