Masking of the endoplasmic reticulum retention signals during assembly of the NMDA receptor.

doi:10.1523/JNEUROSCI.5239-07.2008

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Article

Masking of the endoplasmic reticulum retention signals during assembly of the NMDA receptor.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Mar 2008

Horak Martin, Chang Kai, Wenthold Robert J

Abstract excerpt

NMDA receptors are glutamate-gated ion channels that play important roles in synaptic transmission and excitotoxicity. The functional NMDA receptor is thought to be a heterotetramer composed mainly of two NR1 and two NR2 subunits. Although it is generally accepted that only correctly assembled NMDA receptors can pass the ER quality control, the mechanism underlying this process is not well understood. Using...

Topics

Amino Acid Sequence
Analysis of Variance
Animals
Cells, Cultured
Cerebral Cortex
Chlorocebus aethiops
Embryo, Mammalian
Endoplasmic Reticulum
Gene Expression
Humans
Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Luminescent Proteins

Membrane Potentials

Mutation

Neurons

Patch-Clamp Techniques

Protein Subunits

Protein Transport

Source

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Identifiers

PMID: 18367616
DOI: 10.1523/JNEUROSCI.5239-07.2008
PMCID: PMC6670593

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