Article
Association of Toll-like receptor 4 alleles with symptoms and sensitization to laboratory animals.
The Journal of allergy and clinical immunology - 1 Nov 2008
Pacheco Karin, Maier Lisa, Silveira Lori, Goelz Kelly, Noteware Kristyn, Luna Bevin, du Bois Ron, Murphy Jim, Rose Cecile
Abstract excerpt
BACKGROUND: Researchers and technicians working with laboratory animals (LAs) are exposed to animal allergen and endotoxin, which can interact to potentiate or inhibit symptoms or allergic responses. We hypothesized that functional genetic variants of Toll-like receptor 4 (TLR4), a key surface receptor for endotoxin, interface between worker and workplace and affect animal sensitization, symptoms, or both....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.