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Article

Pyrosequencing as a tool to detect molecular markers of resistance to neuraminidase inhibitors in seasonal influenza A viruses.

Antiviral research - 1 Jan 2009

Deyde Varough M, Okomo-Adhiambo Margaret, Sheu Tiffany G, Wallis Teresa R, Fry Alicia, Dharan Nila, Klimov Alexander I, Gubareva Larisa V

Abstract excerpt

Pyrosequencing has been successfully used to monitor resistance in influenza A viruses to the first class of anti-influenza drugs, M2 blockers (adamantanes). In contrast to M2 blockers, resistance to neuraminidase (NA) inhibitors (NAIs) is subtype- and drug-specific. Here, we designed a pyrosequencing assay for detection of the most commonly reported mutations associated with resistance to NAIs, a newer class of...

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Identifiers

PMID: 18835410
DOI: 10.1016/j.antiviral.2008.08.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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