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A novel pyrosequencing assay for the detection of neuraminidase inhibitor resistance-conferring mutations among clinical isolates of avian H7N9 influenza virus.

Virus research - 22 Jan 2014

Qi Yuhua, Fan Huan, Qi Xian, Zhu Zheng, Guo Xiling, Chen Yin, Ge Yiyue, Zhao Kangchen, Wu Tao, Li Yan, Shan Yunfeng, Zhou Minghao, Shi Zhiyang, Wang Hua, Cui Lunbiao

Abstract excerpt

A novel reassortant avian influenza A virus (H7N9) emerged in humans in Eastern China in late February 2013. All virus strains were resistant to adamantanes (amantadine and rimantadine), but susceptible to neuraminidase inhibitors (NAIs) (oseltamivir and zanamivir). One strain (A/shanghai/1/2013) contained the R294K substitution in the neuraminidase (NA) gene, indicating resistance to oseltamivir. Pyrosequencing...

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Identifiers

PMID: 24211668
DOI: 10.1016/j.virusres.2013.10.026
PMCID: PMC7126809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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