Article
Rapid quantitation of neuraminidase inhibitor drug resistance in influenza virus quasispecies.
Antiviral therapy - 1 Jan 2008
Lackenby Angie, Democratis Jane, Siqueira Marilda M, Zambon Maria C
Abstract excerpt
BACKGROUND: Emerging resistance of influenza viruses to neuraminidase inhibitors is a concern, both in surveillance of global circulating strains and in treatment of individual patients. Current methodologies to detect resistance rely on the use of cultured virus, thus taking time to complete or lacking the sensitivity to detect mutations in viral quasispecies. Methodology for rapid detection of clinically...
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