Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced memory B cells in patients with hyper IgE syndrome.

Clinical immunology (Orlando, Fla.) - 1 Dec 2008

Speckmann C, Enders A, Woellner C, Thiel D, Rensing-Ehl A, Schlesier M, Rohr J, Jakob T, Oswald E, Kopp M V, Sanal O, Litzman J, Plebani A, Pietrogrande M C, Franco J L, Espanol T, Grimbacher B, Ehl S

Abstract excerpt

Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Viral
Share to Antibody Formation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dermatitis, Atopic

Share to Enzyme-Linked Immunosorbent Assay

Share to Immunoglobulin E

Share to Immunologic Memory

Share to Job Syndrome

Share to STAT3 Transcription Factor

Source

Identifiers

PMID: 18835223
DOI: 10.1016/j.clim.2008.08.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced memory B cells in patients with hyper IgE syndrome.PMID 18835223Read ↗

A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.Semantic proximity Read ↗

A novel STAT3 mutation associated with hyper immunoglobulin E syndrome with a paucity of connective tissue signs.Semantic proximity Read ↗

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.Semantic proximity Read ↗

Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey.Semantic proximity Read ↗

Hyper IgE syndrome: an update on clinical aspects and the role of signal transducer and activator of transcription 3.Semantic proximity Read ↗

Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome.Semantic proximity Read ↗

Hyper IgE (Job's) syndrome: a primary immune deficiency with oral manifestations.Semantic proximity Read ↗

Variable clinical expressivity of STAT3 mutation in hyperimmunoglobulin E syndrome: genetic and clinical studies of six patients.Semantic proximity Read ↗

Hyper-IgE syndrome.Semantic proximity Read ↗

Hyper-IgE syndrome with a novel STAT3 mutation-a single center study from India.Semantic proximity Read ↗

Intermediate phenotypes in patients with autosomal dominant hyper-IgE syndrome caused by somatic mosaicism.Semantic proximity Read ↗

TH17 Cells in STAT3 Related Hyper-IgE Syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.