Article
Lack of association between TNF-alpha polymorphisms and Alzheimer's disease in an Italian cohort.
Neuroscience letters - 3 Dec 2008
Tedde Andrea, Putignano Anna Laura, Nacmias Benedetta, Bagnoli Silvia, Cellini Elena, Sorbi Sandro
Abstract excerpt
Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine that plays an important role in the inflammatory process that can be observed in Alzheimer's disease (AD) brain. Different functional promoter polymorphisms within genes modulating inflammation have been demonstrated to elevate the AD risk; thus, we studied five common variations within the promoter region of the TNF-alpha gene in 609 subjects...
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