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Article

Anti-inflammatory effects of interleukin-23 receptor cytokine-binding homology region rebalance T cell distribution in rodent collagen-induced arthritis.

Oncotarget - 31 May 2016

Guo Wei, Yu Dongmei, Wang Xin, Luo Cheng, Chen Yucong, Lei Wen, Wang Chen, Ge Yaoyao, Xue Wenyao, Tian Qiqi, Gao Xiangdong, Yao Wenbing

Abstract excerpt

IL-23 is an important cytokine to regulate Th17 cell differentiation and promote the proliferation of inflammatory cells in Th17-mediated autoimmune diseases. The collagen-induced arthritis (CIA) in rat is a model of rheumatoid arthritis characterized by pronounced inflammatory auto-responses from B and T cells, especially Th17 cells in lesions. In the present study, we used rhIL23R-CHR to block the IL-23...

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Share to Anti-Inflammatory Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interleukin-17

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Share to T-Lymphocytes, Regulatory

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Source

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Identifiers

PMID: 27177334
DOI: 10.18632/oncotarget.9309
PMCID: PMC5077977

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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