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Targeting IGF1 ‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging

30 Mar 2025

Abstract excerpt

The insulin-like growth factor-1 (IGF-1) signaling pathway is known as a potent aging modifier, disruption of which consistently associates with lifespan extension across diverse species. Despite this established association, the mechanisms by which IGF-1 signaling modulates organ aging remain poorly understood. In this study, we assessed age-related changes in IGF-1 expression across multiple organs in mice and...

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PMID: 40159808
DOI: 10.1111/acel.70053

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