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Article

A comparison of relative abundance, activity factor and inhibitory monoclonal antibody approaches in the characterization of human CYP enzymology.

British journal of clinical pharmacology - 1 Feb 2003

Soars Matthew G, Gelboin Harry V, Krausz Kristopher W, Riley Robert J

Abstract excerpt

AIMS: The objective of this study was to evaluate the potential uses of relative abundance, relative activity approaches and inhibitory monoclonal antibodies (mAbs) in the characterization of CYP enzymology in early drug discovery. METHODS: Intrinsic clearance estimates for the oxidation of ethoxyresorufin (a selective probe of CYP1A2 activity), tolbutamide (CYP2C9), S-mephenytoin (CYPC19), dextromethorphan...

Topics

Antibodies, Monoclonal
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System
Drug Design
Humans
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 12580989
DOI: 10.1046/j.1365-2125.2003.01721.x
PMCID: PMC1894739

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