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Article

Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver.

Proteomics - 1 May 2009

Langenfeld Elmar, Zanger Ulrich M, Jung Klaus, Meyer Helmut E, Marcus Katrin

Abstract excerpt

We describe the assay of the human cytochrome P450 2D6 in a set of 30 genotyped liver samples using the 'absolute quantification' (AQUA) technique. We found approximately 30 fmol CYP2D6 per microg of microsomal protein, with the values spanning from 0 to nearly 80 fmol/microg. This is greater by a factor of 5-10 from the compared to the currently accepted value, which was around 5 fmol/microg. Our results thus...

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Identifiers

PMID: 19402041
DOI: 10.1002/pmic.200800680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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