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Article

Expression and relevance of the G protein-gated K+ channel in the mouse ventricle.

Scientific reports - 19 Jan 2018

Anderson Allison, Kulkarni Kanchan, Marron Fernandez de Velasco Ezequiel, Carlblom Nicholas, Xia Zhilian, Nakano Atsushi, Martemyanov Kirill A, Tolkacheva Elena G, Wickman Kevin

Abstract excerpt

The atrial G protein-gated inwardly rectifying K+ (GIRK) channel is a critical mediator of parasympathetic influence on cardiac physiology. Here, we probed the details and relevance of the GIRK channel in mouse ventricle. mRNAs for the atrial GIRK channel subunits (GIRK1, GIRK4), M2 muscarinic receptor (M2R), and RGS6, a negative regulator of atrial GIRK-dependent signaling, were detected in mouse ventricle at...

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Source

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Identifiers

PMID: 29352184
DOI: 10.1038/s41598-018-19719-x
PMCID: PMC5775354

Genes

RGS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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