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Article

Pharmacokinetic Changes during Pregnancy According to Genetic Variants: a Prospective Study in HIV-Infected Patients Receiving Atazanavir-Ritonavir.

Antimicrobial agents and chemotherapy - 1 Jul 2018

Focà Emanuele, Calcagno Andrea, Bonito Andrea, Cusato Jessica, Domenighini Elisabetta, D'Avolio Antonio, Quiros Roldan Eugenia, Trentini Laura, Castelnuovo Filippo, Di Perri Giovanni, Castelli Francesco, Bonora Stefano

Abstract excerpt

Atazanavir-ritonavir concentrations change over time during pregnancy in HIV-positive patients; the impact of genetic variants is unknown. Twenty patients were enrolled in this study; plasma and intracellular concentrations of antiretrovirals were measured, in addition to single-nucleotide polymorphisms in transport-related genes. Linear logistic regression showed that genetic variants in...

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Source

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Identifiers

PMID: 29760129
DOI: 10.1128/AAC.00309-18
PMCID: PMC6021630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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