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Article

CD28 stimulation triggers NF-kappaB activation through the CARMA1-PKCtheta-Grb2/Gads axis.

International immunology - 1 Dec 2008

Takeda Kei, Harada Yohsuke, Watanabe Ryosuke, Inutake Yuu, Ogawa Shuhei, Onuki Kazunobu, Kagaya Saori, Tanabe Kazunari, Kishimoto Hidehiro, Abe Ryo

Abstract excerpt

CD28 stimulation contributes to activation of the IL-2 promoter by up-regulating the activity of several transcription factors, including nuclear factor kappaB (NF-kappaB)/Rel family members. However, the signal-transducing cascades linking the CD28 molecule and activation of NF-kappaB remain unclear. Protein kinase C (PKC) , CARMA1 and Bcl10 have recently been reported to integrate TCR-mediated NF-kappaB...

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PMID: 18829987
DOI: 10.1093/intimm/dxn108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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CD28 stimulation triggers NF-kappaB activation through the CARMA1-PKCtheta-Grb2/Gads axis.PMID 18829987Read ↗

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