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Article

Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells.

The Biochemical journal - 1 Apr 2002

Tao Li, Wadsworth Scott, Mercer Jason, Mueller Cynthia, Lynn Kirsten, Siekierka John, August Avery

Abstract excerpt

T-cell activation requires signals from both the T-cell receptor (TcR) and other co-stimulatory molecules such as CD28. TcR- and CD28-mediated signals are integrated during T-cell activation resulting in the expression of cytokine genes such as interleukin-2 (IL-2). An enhancer element (CD28RE) of the IL-2 gene specifically responsive to CD28 signals has been previously identified and characterized. This response...

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Identifiers

PMID: 11903060
DOI: 10.1042/0264-6021:3630175
PMCID: PMC1222464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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