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Article

Striatal dopamine D2 receptors, metabolism, and volume in preclinical Huntington disease.

Neurology - 27 Sept 2005

van Oostrom J C H, Maguire R P, Verschuuren-Bemelmans C C, Veenma-van der Duin L, Pruim J, Roos R A C, Leenders K L

Abstract excerpt

Among 27 preclinical carriers of the Huntington disease mutation (PMC), the authors found normal striatal values for MRI volumetry in 88% and for fluorodesoxyglucose PET metabolic index in 67%. Raclopride PET binding potential (RAC-BP) was decreased in 50% and correlated with increases in the product of age and CAG repeat length (p < 0.0005). Dopamine D2 receptor availability measured by RAC-BP seems the most...

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Identifiers

PMID: 16186542
DOI: 10.1212/01.wnl.0000176071.08694.cc

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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