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Article

A combined binary interaction and phenotypic map of C. elegans cell polarity proteins.

Nature cell biology - 1 Mar 2016

Koorman Thijs, Klompstra Diana, van der Voet Monique, Lemmens Irma, Ramalho João J, Nieuwenhuize Susan, van den Heuvel Sander, Tavernier Jan, Nance Jeremy, Boxem Mike

Abstract excerpt

The establishment of cell polarity is an essential process for the development of multicellular organisms and the functioning of cells and tissues. Here, we combine large-scale protein interaction mapping with systematic phenotypic profiling to study the network of physical interactions that underlies polarity establishment and maintenance in the nematode Caenorhabditis elegans. Using a fragment-based yeast...

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Identifiers

PMID: 26780296
DOI: 10.1038/ncb3300
PMCID: PMC4767559

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