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Article

Analysis of thiopurine S-methyltransferase genotypes in Japanese patients with inflammatory bowel disease.

Internal medicine (Tokyo, Japan) - 1 Jan 2008

Ban Hiromitsu, Andoh Akira, Tanaka Aiko, Tsujikawa Tomoyuki, Sasaki Masaya, Saito Yasuharu, Fujiyama Yoshihide

Abstract excerpt

BACKGROUND AND AIMS: Myelosuppression observed in patients with inflammatory bowel disease (IBD) treated with azathioprine (AZA) has been attributed to low thiopurine S-methyltransferase (TPMT) activity. TPMT activity is dependent on the genetic polymorphism of high-versus low-metabolizing alleles. We investigated the association between TPMT genotypes and myelosuppression in Japanese IBD patients. METHODS:...

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Source

Identifiers

PMID: 18827410
DOI: 10.2169/internalmedicine.47.1268

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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