Article
Limitations of extensive TPMT genotyping in the management of azathioprine-induced myelosuppression in IBD patients.
Clinical biochemistry - 1 Sept 2011
Dewit O, Moreels T, Baert F, Peeters H, Reenaers C, de Vos M, Van Hootegem Ph, Muls V, Veereman G, Mana F, Van Outryve M, Holvoet J, Naegels S, Piessevaux H, Horsmans Y, Gala J L
Abstract excerpt
BACKGROUND AND AIMS: TPMT deficiency is associated with azathioprine (AZA)-induced myelosuppression (MS). However, in one previous study, only about ¼ of MS episodes in Crohn's Disease patients under AZA can be attributed to TPMT deficiency. Recently, new TPMT mutations have been described and our aim is to investigate their clinical relevance before and after a first MS episode on thiopurine therapy. METHODS:...
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