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Disentangling the Frames, the State of Research on the Alphavirus 6K and TF Proteins

18 Aug 2017

Abstract excerpt

For 30 years it was thought the alphavirus 6K gene encoded a single 6 kDa protein. However, through a bioinformatics search 10 years ago, it was discovered that there is a frameshifting event and two proteins, 6K and transframe (TF), are translated from the 6K gene. Thus, many functions attributed to the 6K protein needed reevaluation to determine if they properly belong to 6K, TF, or both proteins. In this...

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PMID: 28820485
DOI: 10.3390/v9080228

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